abstract：:Matrix metalloproteinase-9 (MMP-9) has been reported to be expressed in various inflammatory disorders including human T cell lymphotropic virus type I (HTLV-I) associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-I-infected T-cells expressed high levels of MMP-9 via viral transactivator Tax mediated act...

journal_title：Journal of neuroimmunology

authors： Kodama D,Saito M,Matsumoto W,Sabouri AH,Izumo S,Arimura K,Usuku K,Bangham CR,Osame M

更新日期：2004-11-01 00:00:00

abstract：:Hemokinin 1 is encoded by preprotachykinin C (PPT-C) mRNA, and has been proposed as a regulator of B and T cell lymphopoiesis. Here we demonstrate the expression of mouse PPT-C mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. Expression was detected in freshly isolated CD11...

journal_title：Journal of neuroimmunology

authors： Nelson DA,Marriott I,Bost KL

更新日期：2004-10-01 00:00:00

abstract：:The microglial inflammatory response to Abeta(1-42) stimulation with or without IFN-gamma priming was investigated in low and high responder strains of mice, A/J and C57BL/6, respectively. A/J microglia showed moderate morphological changes upon stimulation with IFN-gamma alone or with Abeta(1-42). Conversely, C57BL/6...

journal_title：Journal of neuroimmunology

authors： Dudal S,Morissette C,Lacombe D,Tremblay P,Gervais F

更新日期：2004-08-01 00:00:00

abstract：:Microglia cells are the principal immune effector elements of the brain responding to any pathological event. To elucidate the possible role of microglia in initial non-inflammatory demyelination in canine distemper virus (CDV) infection, microglia from experimentally CDV infected dogs were isolated ex vivo by density...

journal_title：Journal of neuroimmunology

authors： Stein VM,Czub M,Schreiner N,Moore PF,Vandevelde M,Zurbriggen A,Tipold A

更新日期：2004-08-01 00:00:00

abstract：:Fas (CD95) and Fas ligand (FasL, CD95L) have been implicated to be involved in the acute inflammatory response by attracting neutrophils and regulating their survival. Increased levels of soluble Fas and FasL are found in cerebrospinal fluid (CSF) samples of patients with bacterial meningitis but not in controls. Func...

journal_title：Journal of neuroimmunology

authors： Paul R,Angele B,Sporer B,Pfister HW,Koedel U

更新日期：2004-07-01 00:00:00

abstract：:The hypothesis of an immune dysfunction in autism spectrum disorders has previously been put forward without, however, compelling evidence of a direct relation to its etiology or pathogenesis. To further understand if autoimmunity could play a significant role in autism, we analyzed autoantibody repertoires to brain t...

journal_title：Journal of neuroimmunology

authors： Silva SC,Correia C,Fesel C,Barreto M,Coutinho AM,Marques C,Miguel TS,Ataide A,Bento C,Borges L,Oliveira G,Vicente AM

更新日期：2004-07-01 00:00:00

abstract：:We have established a mouse experimental brain abscess model using Staphylococcus aureus where lesion sites are greatly exaggerated compared to the localized area of initial infection, reminiscent of an overactive immune response. Here we demonstrate the prolonged expression of IL-1 beta, TNF-alpha, and macrophage inf...

journal_title：Journal of neuroimmunology

authors： Baldwin AC,Kielian T

更新日期：2004-06-01 00:00:00

abstract：:VCAM-1 is an adhesion molecule that is important to leukocyte movement across the blood-brain barrier and is involved in the formation of destructive CNS inflammatory lesions in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). We examined VCAM-1 expression in the CNS of animals with passive...

journal_title：Journal of neuroimmunology

authors： Gimenez MA,Sim JE,Russell JH

更新日期：2004-06-01 00:00:00

abstract：:The role of nitric oxide (NO) in central nervous system (CNS) inflammation is uncertain. Whereas experimental autoimmune encephalomyelitis (EAE) is exacerbated in mice deficient in inducible nitric oxide synthase (iNOS), inhibitor studies have suggested a pro-inflammatory role for NO. These discrepancies may reflect b...

journal_title：Journal of neuroimmunology

authors： Zehntner SP,Bourbonniere L,Hassan-Zahraee M,Tran E,Owens T

更新日期：2004-05-01 00:00:00

abstract：:We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with susceptibility and severity of multiple sclerosis (MS) in Japanese. DNA was collected from 216 patients with clinically definite MS (65 opticospinal MS (OS-MS) and 151 ...

journal_title：Journal of neuroimmunology

authors： Osoegawa M,Niino M,Ochi H,Kikuchi S,Murai H,Fukazawa T,Minohara M,Tashiro K,Kira J

更新日期：2004-05-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is an important autoantigen in multiple sclerosis and in experimental autoimmune encephalomyelitis (EAE). We generated a T cell receptor (TCR) transgenic (Tg) mouse expressing a TCR derived from an encephalitogenic T cell clone specific for MOG(35-55). This mouse failed to dev...

journal_title：Journal of neuroimmunology

authors： Mendel I,Natarajan K,Ben-Nun A,Shevach EM

更新日期：2004-04-01 00:00:00

abstract：:The purpose of this study was to determine if alpha-tocopherol-a reactive oxygen species (ROS) scavenging agent-inhibits LPS-induced oxidative stress and interleukin-6 (IL-6) production in murine microglia and brain. LPS increased intracellular peroxides and IL-6 in a dose-dependent fashion in primary microglia. The L...

journal_title：Journal of neuroimmunology

authors： Godbout JP,Berg BM,Kelley KW,Johnson RW

更新日期：2004-04-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) is not only involved in cell death but also in other immunoregulatory mechanisms. So far, the regulation of the TRAIL pathway in physiologic and pathologic conditions remains unclear. Due to the implication in brain damage and the elevated expression in peripheral immune c...

journal_title：Journal of neuroimmunology

authors： Weber A,Wandinger KP,Mueller W,Aktas O,Wengert O,Grundström E,Ehrlich S,Windemuth C,Kuhlmann T,Wienker T,Brück W,Zipp F

更新日期：2004-04-01 00:00:00

abstract：:To explore the possible contribution of thymic myoid cells in tolerance induction mechanisms, we quantified by real-time RT-PCR, the expression of 12 muscle genes (the five subunits of acetylcholine receptor, Musk, rapsyn, utrophin, ErbB2, ErbB3, troponin T, and MCK) in a human thymic myoid cell line (MITC), compared ...

journal_title：Journal of neuroimmunology

authors： Mesnard-Rouiller L,Bismuth J,Wakkach A,Poëa-Guyon S,Berrih-Aknin S

更新日期：2004-03-01 00:00:00

abstract：:Two pairs of monozygotic twins, discordant for myasthenia gravis (MG) for more than 30 years, were studied regarding T cell and antibody reactivity against disease related autoantigens, the acetylcholine receptor, one idiotypic and one anti-idiotypic human monoclonal antibody. The healthy and myasthenic twins had very...

journal_title：Journal of neuroimmunology

authors： Kakoulidou M,Ahlberg R,Yi Q,Giscombe R,Pirskanen R,Lefvert AK

更新日期：2004-03-01 00:00:00

abstract：:Potential interactions between psychostimulant drugs and infection with feline immunodeficiency virus (FIV) on brain metabolism were evaluated. Four groups of cats were studied: control, FIV positive, methamphetamine (MA) exposed, and FIV positive plus MA exposed. Frontal gray matter, frontal white matter, and caudate...

journal_title：Journal of neuroimmunology

authors： Cloak CC,Chang L,Ernst T,Barr MC,Huitron-Resendiz S,Sanchez-Alavez M,Phillips TR,Henriksen S

更新日期：2004-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) produced by activated microglia are deleterious to neurons. In this study, we studied the effect of Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (MnTMPyP), a superoxide dismutase/catalase mimetic, on the lipopolysaccharide (LPS)-induced degeneration of dopaminergic neurons in rat mesencep...

journal_title：Journal of neuroimmunology

authors： Wang T,Liu B,Qin L,Wilson B,Hong JS

更新日期：2004-02-01 00:00:00

abstract：:Previously, our laboratory showed that either abrupt (AW) or precipitated withdrawal (PW) from morphine led to profound suppression of murine splenic antibody responses to sheep red blood cells at 24 h post-withdrawal. In the present studies, we examined the immune mechanisms mediating suppression at that time point. ...

journal_title：Journal of neuroimmunology

authors： Rahim RT,Feng P,Meissler JJ,Rogers TJ,Zhang L,Adler MW,Eisenstein TK

更新日期：2004-02-01 00:00:00

abstract：:After an injury to the central nervous system (CNS), activated microglia have been shown to contribute to the ongoing destructive processes leading to secondary neuronal degeneration. They can, however, also express neuroprotective activity. Studies from our laboratory point to the existence of a physiological T cell-...

journal_title：Journal of neuroimmunology

authors： Shaked I,Porat Z,Gersner R,Kipnis J,Schwartz M

更新日期：2004-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are believed to play a role in the pathogenesis of multiple sclerosis (MS). As methylprednisolone is the treatment of choice for a relapse, we investigated the effect of methylprednisolone on blood levels of MMPs. Baseline TIMP-1 and MMP-2 levels were lower in MS patients than in healt...

journal_title：Journal of neuroimmunology

authors： Mirowska D,Wicha W,Czlonkowski A,Czlonkowska A,Weber F

更新日期：2004-01-01 00:00:00

abstract：:In the present work we investigated on rat splenocytes long-term interactions between opioid and cannabinoid drugs in terms of a common regulation of cAMP intracellular pathway. Both morphine and the synthetic cannabinoid compound CP-55,940 inhibited in a concentration-dependent manner the intracellular cAMP level in ...

journal_title：Journal of neuroimmunology

authors： Massi P,Vaccani A,Rubino T,Parolaro D

更新日期：2003-12-01 00:00:00

abstract：:Nogo-A is a protein associated with central nervous system (CNS) myelin thought to impair regenerative responses and to suppress sprouting and plastic changes of synaptic terminals. In this study, we report that serum IgM autoantibodies to the recombinant large N-terminal inhibitory domain of Nogo-A are a frequent fin...

journal_title：Journal of neuroimmunology

authors： Reindl M,Khantane S,Ehling R,Schanda K,Lutterotti A,Brinkhoff C,Oertle T,Schwab ME,Deisenhammer F,Berger T,Bandtlow CE

更新日期：2003-12-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) is a well-characterized murine model of the chronic-progressive form of human multiple sclerosis (MS) characterized by the activation of myelin-specific autoreactive CD4 Th1 cells via epitope spreading. To gain an understanding of the po...

journal_title：Journal of neuroimmunology

authors： Mack CL,Vanderlugt-Castaneda CL,Neville KL,Miller SD

更新日期：2003-11-01 00:00:00

abstract：:In 1996, we reported the results of a linkage genome screen based on 129 UK multiple sclerosis multiplex families, together with follow-up typing of interesting regions in a second set of families. We have now completed screening the remainder of the genome in this second set of United Kingdom families by typing 242 m...

journal_title：Journal of neuroimmunology

authors： Hensiek AE,Roxburgh R,Smilie B,Coraddu F,Akesson E,Holmans P,Sawcer SJ,Compston DA

更新日期：2003-10-01 00:00:00

abstract：:Although the pathogenesis of multiple sclerosis (MS) is not fully understood, substantial evidence points to the involvement of genetic factors. We report on a genome-wide screen for disease association in the Hungarian population using 5532 microsatellite markers. These markers were typed in DNA pools that consisted ...

journal_title：Journal of neuroimmunology

authors： Rajda C,Bencsik K,Seres E,Jonasdottir A,Foltynie T,Sawcer S,Benediktsson K,Fossdal R,Setakis E,Compston A,Vécsei L

更新日期：2003-10-01 00:00:00

abstract：:In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) protocol. Twelve markers showing evidence for as...

journal_title：Journal of neuroimmunology

authors： Eraksoy M,Hensiek A,Kurtuncu M,Akman-Demir G,Kilinc M,Gedizlioglu M,Petek-Balci B,Anlar O,Kutlu C,Saruhan-Direskeneli G,Idrisoglu HA,Setakis E,Compston A,Sawcer S,Turkish Multiple Sclerosis Genetics Study Group.

更新日期：2003-10-01 00:00:00

abstract：:Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The...

journal_title：Journal of neuroimmunology

authors： Bomstein Y,Marder JB,Vitner K,Smirnov I,Lisaey G,Butovsky O,Fulga V,Yoles E

更新日期：2003-09-01 00:00:00

abstract：:Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human pe...

journal_title：Journal of neuroimmunology

authors： Shibata A,Zelivyanskaya M,Limoges J,Carlson KA,Gorantla S,Branecki C,Bishu S,Xiong H,Gendelman HE

更新日期：2003-09-01 00:00:00

abstract：:Previously, we found that in rats coagulation of the lateral hypothalamus (LH) caused depression of the peripheral blood natural killer cell cytotoxicity (NKCC) and the number of large granular lymphocytes (LGL). In the present work, we have tested the effects on both spleen and blood NKCC of acute (1 day) and chronic...

journal_title：Journal of neuroimmunology

authors： Wrona D,Trojniar W

更新日期：2003-08-01 00:00:00

abstract：:SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot of chick retinal proteins at 21 days after intravitreal injection with 5 or 10 microM/eye Glu showed decreases in 37, 42, 53 and 57 kDa proteins and increases in 35, 72 and >94 kDa proteins. These proteins were carboxylases except for the 35 and 37 kDa...

journal_title：Journal of neuroimmunology

authors： Sattayasai N,Sattayasai J,Daduang S,Chahomchuen T,Ketkaew S,Puchongkavarin H

更新日期：2003-08-01 00:00:00

abstract：:Nitric oxide (NO) is implicated in inflammation and hypothalamic-pituitary responses to immune stimuli; however, the specific role of NO from neurons during stress-induced immune responses remains unspecified. We measured antigen-specific delayed-type-hypersensitivity (DTH) responses in the skin of wild-type (WT) and ...

journal_title：Journal of neuroimmunology

authors： Bilbo SD,Hotchkiss AK,Chiavegatto S,Nelson RJ

更新日期：2003-07-01 00:00:00

abstract：:The expression of interleukin-1 beta (IL-1beta) mRNA was compared in the brain of inflammatory susceptible LEW/N and resistant F344/N rats at 3, 6, and 12 h after peripheral administration of lipopolysaccharide (LPS) or saline. No differences between strains were observed in the circumventricular organs (CVOs) and cho...

journal_title：Journal of neuroimmunology

authors： Tonelli LH,Maeda S,Rapp KL,Sternberg EM

更新日期：2003-07-01 00:00:00

abstract：:Thirty patients with clinically isolated syndromes (CIS) were evaluated at the onset of neurological symptoms and when they developed clinically definite MS (CDMS). Surface expression of LFA-1alpha, VLA-4 and intercellular adhesion molecule-1 (ICAM-1) on PBMC and CSF cells was evaluated using flow cytometry. Serum and...

journal_title：Journal of neuroimmunology

authors： Correale J,Bassani Molinas Mde L

更新日期：2003-07-01 00:00:00

abstract：:Neuronal damage in Alzheimer's disease (AD) is thought to involve direct toxicity of beta-amyloid peptide (Abeta) and excitotoxicity involving NMDA receptors (NMDARs) and altered Ca(2+) dynamics. Inflammation agents produced by microglia or astrocytes and associated with senile plaques such as the cytokine interleukin...

journal_title：Journal of neuroimmunology

authors： Qiu Z,Gruol DL

更新日期：2003-06-01 00:00:00

abstract：:The efficacy of plasma exchange as a therapy for Guillain-Barré syndrome (GBS) suggests that humoral factors might contribute to the axonal conduction block responsible for the major symptoms of the disease. To explore this possibility, we have applied sera to rat spinal roots in vitro while monitoring axonal conducti...

journal_title：Journal of neuroimmunology

authors： Dilley A,Gregson NA,Hadden RD,Smith KJ

更新日期：2003-06-01 00:00:00

abstract：:To determine the role of endogenous interleukin-18 (IL-18) in pneumococcal meningitis, meningitis was induced in IL-18 gene-deficient (IL-18(-/-)) and wild-type (WT) mice by intranasal inoculation of Streptococcus pneumoniae with hyaluronidase. Induction of meningitis resulted in an upregulation of both pro- and matur...

journal_title：Journal of neuroimmunology

authors： Zwijnenburg PJ,van der Poll T,Florquin S,Akira S,Takeda K,Roord JJ,van Furth AM

更新日期：2003-05-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) are proteases involved in extracellular matrix (ECM) remodeling, leukocyte infiltration into lesions and myelin degradation in the central nervous system (CNS) disease multiple sclerosis (MS). We have investigated whether MMP-12 (macrophage metalloelastase) is expressed in MS lesions a...

journal_title：Journal of neuroimmunology

authors： Vos CM,van Haastert ES,de Groot CJ,van der Valk P,de Vries HE

更新日期：2003-05-01 00:00:00

abstract：:G-protein-coupled receptors (GPCR) play an important role in inflammation. Their responsiveness is regulated by G-protein-coupled receptor kinases (GRKs) and beta-arrestins. We show here that induction of experimental autoimmune encephalomyelitis (EAE) by myelin oligodendrocyte glycoprotein (MOG) resulted in a profoun...

journal_title：Journal of neuroimmunology

authors： Vroon A,Lombardi MS,Kavelaars A,Heijnen CJ

更新日期：2003-04-01 00:00:00

abstract：:IFN-gamma production is a hallmark of Th1 response, and IFN-gamma has multiple roles in Th1 development, depending on the experimental conditions. In this study, the correlation between IFN-gamma and interleukin 12 receptor beta2 (IL-12R beta 2) expression was investigated in experimental autoimmune uveitis (EAU) susc...

journal_title：Journal of neuroimmunology

authors： Wu Y,Lin Y,Hou W,Wang Y,Sun B

更新日期：2003-04-01 00:00:00

abstract：:Immunization with the whole cell pertussis vaccine (Pw), but not the acellular pertussis vaccine (Pa), is associated with a number of neurological side effects. Previously, we have demonstrated a role for interleukin-1beta (IL-1beta) in Pw reactogenicity. Here we report that parenteral Pw administration resulted in a ...

journal_title：Journal of neuroimmunology

authors： Armstrong ME,Loscher CE,Lynch MA,Mills KH

更新日期：2003-03-01 00:00:00